Functional Neuroconnectomics

  1. DeepLabStream enables closed-loop behavioral experiments using deep learning-based  markerless, real-time posture detection.Schweihoff JF, Loshakov M, Pavlova I, Kück L, Ewell L, Schwarz MK.Commun. Biol. 2021 Jan 29;4(1):130.
  2. Epothilones Improve Axonal Growth and Motor Outcomes after Stroke in the AdultMammalian CNS.Kugler C, Thielscher C, Tambe BA, Schwarz MK, Halle A, Bradke F, Petzold GC.Cell Rep Med. 2020 Dec 22;1(9):100159.
  3. The Diagonal Band of Broca continually regulates olfactory-mediated behaviors.Schwarz I,Müller M, Pavlova I, Schweihoff JF, Musacchio F, Mittag M, Fuhrmann M, Schwarz MK bioRxiv (2020) doi: 10.1101/2020.11.07.372649
  4. Local efficacy of glutamate uptake decreases with synapse size.Herde MK, Bohmbach K, Domingos C, Vana N, Komorowska-Müller JA, Passlick S,Schwarz I, Jackson CJ, Dietrich D, Schwarz MK, Henneberger C.Cell Rep. 2020 Sep 22;32(12):108182.
  5. Social touch promotes interfemale communication via activation of parvocellular oxytocinneurons.Tang Y, Benusiglio D, Lefevre A, Hilfiger L, Althammer F, Bludau A, Hagiwara D, Baudon A,Darbon P, Schimmer J, Kirchner MK, Roy RK, Wang S, Eliava M, Wagner S, Oberhuber M,Conzelmann KK, Schwarz MK, Stern JE, Leng G, Neumann ID, Charlet A, Grinevich V.Nat Neurosci. 2020 Jul 27. doi: 10.1038/s41593-020-0674-y .
  6. Cortical layer 6 control of sensory responses in higher-order thalamus.Ansorge J, Humanes-Valera D, Pauzin FP, Schwarz MK, Krieger P.J Physiol. 2020 Jun 30. doi: 10.1113/JP279915 .
  7. Hard-wired lattice light sheet microscopy for imaging of expanded samples.Stockhausen A, Bürgers J, Rodriguez-Gatica JE, Schweihoff J, Merkel R, PriggeJM, Schwarz MK, Kubitscheck U.Opt Express. 2020 May 11;28(10):15587-15600. doi: 10.1364/OE.393728 .
  8. Enhanced adenosine A1 receptor and Homer1a expression in hippocampus modulates theresilience to stress-induced depression-like behavior.Serchov T, Schwarz I, Theiss A, Sun L, Holz A, Döbrössy MD, Schwarz MK, Normann C,Biber K, van Calker D.Neuropharmacology. 2020 Jan 1;162:107834. doi: 10.1016/j.neuropharm.2019.107834 .Epub 2019 Nov 1.
  9. A New Projection from Deep Cerebellar Nuclei to the Hippocampus via the Ventrolateral andLaterodorsal Thalamus in Mice.Bohne P, Schwarz MK, Herlitze S, Mark MD.Front Neural Circuits. 2019 Aug 9;13:51. doi: 10.3389/fncir.2019.00051 . eCollection 2019.Enhanced
  10. mGlu5Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects viaAMPA Receptor ctivation.Holz A, Mülsch F, Schwarz MK, Hollmann M, Döbrössy MD, Coenen VA, Bartos M,Normann C, Biber K, van Calker D, Serchov T.Neuron. 2019 Oct 23;104(2):338-352.e7. doi: 10.1016/j.neuron.2019.07.011 . Epub 2019Aug 13.
  11. Rabies virus-mediated connectivity tracing from single neurons.Schwarz MK, Remy S.J Neurosci Methods. 2019 Sep 1;325:108365. doi: 10.1016/j.jneumeth.2019.108365 . Epub2019 Jul 19.
  12. The in vivo timeline of differentiation of engrafted human neuronal progenitor cells.Vogel S, Schäfer C, Hess S, Folz-Donahue K, Nelles M, Minassian A, Schwarz MK, KukatC, Ehrlich M, Zaehres H, Kloppenburg P, Hoehn M, Aswendt M.Stem Cell Res. 2019 May;37:101429. doi: 10.1016/j.scr.2019.101429  . Epub 2019 Mar 25.
  13. Light sheet fluorescence expansion microscopy: fast mapping of neuronal circuits at superresolution.Bürgers J, Pavlova I, Rodriguez-Gatica JE, Henneberger C, Oeller M, Ruland JA, SiebrasseJP, Kubitscheck U, Schwarz MK. Neurophotonics. 2019 Jan;6(1):015005. doi: 10.1117/1.NPh.6.1.015005  . Epub 2019 Feb 8.
  14. Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior. Lecca, S., Meye, FJ., Trusel, M., Tchenio, A., Harris, J., Schwarz, MK., Burdakov, D., Georges, F., Mameli, M. eLife (2017) 5:6 Pii:e30697. Doi: 10.7554/eLife.30697 .
  15. Subcelluler reorganization and altered phosphorylation of the gap junction protein connexin43 in human experimental epilepsy. Deshpande, T., Li, T., Herde, M., Becker, A., Vatter, H., Schwarz, MK., Henneberger, C., Steinhäuser, C., Bedner, P. Glia (2017) 65(11):1809-1820.
  16. Adrenergic Gate Release for Spike Timing-Dependent Synaptic Potentiation. Liu, Y., Cui, L., Schwarz, MK., Dong, Y., Schlüter, OM. Neuron (2017) 93: 394-408.
  17. Whole-brain mapping of human neural transplant innervation. Doerr, J*., Schwarz, M.K*., Wiedermann, D., Leinhaas, A., Jakobs, A., Schloen, F., Schwarz, I., Diedenhofen, M., Braun, NC., Koch, P., Peterson, DA., Kubitscheck, U., Hoehn, M., Bruestle, O. Nat. Communications (2017), 8:14162; DOI: 10.1038
  18. Glutamatergic synaptic integration of locomotion speed via septo-entorhinal projections. Justus, D., Daluegge, D., Bothe, S., Fuhrmann, F., Hannes, C., Kaneko, H., Friedrichs, D., Sosulina, L., Schwarz, I., Elliott, DA., Schoch, S., Bradke, F., Schwarz, M.K., Remy, S. Nat. Neurosci. (2017) 20:16-19.
  19. Dysfunction of Somatostatin-Positive Interneurons in an Alzheimer’s Disease Model. Schmid, LC., Mittag, M., Poll, S., Steffen, J., Wagner, J., Geis, HR., Schwarz, I., Schmidt, B., Schwarz, M.K., Remy, S., Fuhrmann, M. Neuron (2016), 92(1):114-125.
  20. Shifted pallidal GABA/Glutamate corelease in habenula drives cocaine withdrawal and relapse. Meye, FJ., Soiza-Reilly, M., Diana, MA., Schwarz, M.K., Mameli, M. Nat. Neurosci. (2016), 19:1019-24.
  21. Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. Serchov, T., Clement, H-W., Schwarz, M.K., Iasevoli, F., Tosh, D.K., Idzko, M., Jacobson, K.A., Bartolomeis, A., Normann, C., Biber, K., van Calker, D. Neuron. (2015), 87(3): 549-562
  22. Locomotion, Theta Oscillations, and Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit. Fuhrmann, F., Justus, D., Sosulina, L., Kaneko, H., Beutel, T., Friedrichs, D., Schoch, S., Schwarz, M.K., Fuhrmann, M., Remy, S. Neuron. (2015), 86(5): 1245-1264
  23. Fluorescent-Protein Stabilization and High-Resolution Imaging of Cleared, Intact Mouse Brains. Schwarz, M. K., Scherbarth, A., Sprengel, R., Engelhardt, J., Theer, P., Giese, G. PlosOne. (2015), DOI:10.1371
  24. Maturation of postnatally generated olfactory bulb granule cells depends on functional gamma-protocadherin expression. Ledderose, J., Stumpf, S., Schwarz, M.K. Scientific Reports. (2013),3:1514.
  25. Charting olfactory connectivity maps by two-color light-sheet fluorescence microscopy. Niedworok, C., Schwarz, I., Ledderose, J., Giese, G., Conzelmann, K.K., Schwarz, M.K. Cell Reports. (2012),2(5):1375-86.
  26. Homer1 gene products orchestrate Ca2+-permeable AMPA receptor distribution and LTP expression. Rozov, A., Zivkovic., A., Schwarz, M. K. Frontiers in Neuroscience. (2012),4:1-10.
  27. Evoked axonal oxytocin release in the central amygdala attenuates fear response. Knobloch, S., Charlet, A., Hoffmann, L.C., Eliava, M., Khrulev, S., Cetin, A.H., Osten, P., Schwarz, M. K., Seeburg, P.H., Stoop, R., Grinevich, V. Neuron. (2012 ),73(3):553-66.
  28. Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer 1 knockout mice by recombinant adeno-associated viral gene delivery of Homer1c. Gerstein, H., O’Riordan, K., Osting, S., Schwarz, M.K., Burger, C. Neurobiology of Learning. (2012),97(1):17-29.
  29. Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout mice. Grinevich, V., Jezova, D., Gambaryan, S., Illarionova, A., Kolleker, A., Seeburg, P.H., Schwarz, M.K. Horm Metab Res. (2011),43(8):551-6.
  30. Transfection via whole-cell recording in vivo: bridging single-cell physiology, genetics and connectomics. Rancz, E.A., Franks, K.M., Schwarz, M.K., Pichler, B., Schaefer, A., Margrie, T.W. Nat. Neuroscience. (2011),14(4): 527-32.
  31. Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Hu, J.H., Park, J.M., Park, S., Xiao, B., Dehoff, M.H., Kim, S., Hayashi, T., Schwarz, M.K., Huganir, R.L., Seeburg, P.H., Linden, D.J., Worley, P.F. Neuron. (2010),68(6):1128-42.
  32. Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear. Tronson, N.C., Guzman, Y.F., Guedea, A.L., Huh, K.H., Gao, C., Schwarz, M.K., Radulovic J.Biol. Psychiatry. (2010),68(11):1007-15.
  33. Rapid and long-lasting transduction of neurons by targeted, recombinant virus injection into the neonatal mouse brain. Pilpel, N., Landeck, N., Klugmann, M., Seeburg, P.H., Schwarz, M.K. Journal of Neuroscience Methods. (2009),182:55-63.
  34. Complex, multimodal behavioral profile of the Homer 1 knockout mouse. Jaubert, P.J., Golub, M.S., Lo, Y.Y., Germann, S.L., Dehhoff, M.H., Worley, P.F., Schwarz, M.K., Seeburg, P.H., Berman R.F. Genes, Brain and Behavior. (2007),6:141-154.
  35. Select overexpression of Homer 1a in dorsal hippocampus impairs spatial working memory. Celikel, T., Marx, V., Zivkovic, A., Rozov, A., Licznerski, P., Osten, P., Hasan, M., Seeburg P.H., Schwarz M.KFrontiers in Neuroscience. (2007),1:97-110.
  36. Combinatorial expression of - and -Protocadherins alters their presenilin-dependent processing. Bonn, S., Seeburg, P.H., Schwarz, M.K. MCB. (2007),27(11):4121-32.
  37. Distinct roles for different Homer 1 isoforms in behaviors and associated prefrontal cortex cortex function. Lominac, K.D., Oleson, E.B., Pava, M., Klugmann, M., Schwarz, M.K., Seeburg, P.H., During, M.J., Worley, P.F., Kalivas, P.W., Szumlinski, K.K. Neuroscience. (2005),14:11586-11594.
  38. Behavioral and neurochemical phenotyping of Homer 1 mutant mice: possible relevance to schizophrenia. Szumlinski, K.K., Lominac, K.D., Kleschen, M.J., Oleson, E.B., Dehoff, M.H., Schwarz, M.K., Seeburg, P.H., Worley, P.F., Kalivas, P.W. Genes, Brain and Behavior. (2005),4:273-288.
  39. -Protocadherins: presenilin-mediated release of c-terminal fragment promotes locus expression. Hambsch, B., Grinevich, V., Seeburg, P.H., Schwarz, M.K. JBC. (2005),22:15888-97.
  40. Reinvestigation of the role of Snapin in neurotransmitter release. Vites, O., Rhee, J.-S., Schwarz, M.K., Rosenmund, C., Jahn, R. JBC. (2004),25:26251-26256 .
  41. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Yuan, J.P., Kiselyov, K., Shin, D.M., Chen, J., Shcheynikov, N., Kang, S., Dehoff, M.H., Schwarz, M.K., Seeburg, P.H., Mullaem, S., Worley, P.F. Cell. (2003),114;777-789.
  42. Synaptic activity induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. Bottai, D., Guzowski, J.F., Schwarz, M.K., Kang,S.H., Xiao, B., Lanahan, A., Worley, P.F., Seeburg, P.H. Neuroscience. (2002),22:167-175.
  43. Dominance of the Lurcher mutation in heteromeric kainate and AMPA receptor channels. Schwarz, M.K., Pawlak, V., Osten, P., Mack, V., Seeburg, P.H., Köhr, G. European Journal of Neuroscience. (2001),14:861-868.
  44. Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. Schwarz, M.K., Cecconi, F., Bernier, G., Andrejewski, A., Kammandel, B., Wagner, M., Gruss, P. Development. (2000),127:4325-4334.
  45. Pax2/5 and Pax6 subdivide the early neural tube into three domains. Schwarz, M.K., Alvarez-Bolado, G., Urbanek, P., Dressler, G., Busslinger, M., Gruss, P. Mechanisms of Development. (1999),82:1-9.
  46. Conserved biological function between Pax2 and Pax5 in midbrain and cerebellum development: Evidence from targeted mutations. Schwarz,  M.K., Alvarez-Bolado,  G., Urbanek, P., Busslinger, M., Gruss, P. PNAS. (1997),94:14518-14523.

Review articles

The structural and functional evidence for vesicular release from astrocytes in situ.

Bohmbach K, Schwarz MK, Schoch S, Henneberger C. Brain Res Bull.

2017 Jan 22. pii: S0361-9230(17)30034-5. doi:

Whole-Brain Microscopy Meets In Vivo Neuroimaging: Techniques, Benefits and Limitations.

Aswendt, M., Schwarz, M., Abdelmoula, WM., Dijkstra, J., Dedeurwaerdere S.

Mol. Imaging Biol. (2016).

Revealing the secrets of neuronal circuits with recombinant rabies virus technology.

Ginger, M., Haberl, M., Conzelmann, K-K., Schwarz, M.K., Frick, A.

Frontiers in Neuroscience. (2013).

Homer 1: a new player linking the hypothalamic-pituitary-adrenal axis activity to depression and anxiety.

Grinevich, V., Seeburg, P.H., Schwarz, M.K., Jezova, D.

Endocrine Regulations. (2012).

Musterbildung im Nervensystem der Wirbeltiere.

Schwarz, M.K., Alvarez-Bolado, G., Gruss, P.

Neuroforum. (1998).

Pax-2 in the chiasm.

Alvarez-Bolado, G., Schwarz, M.K., Gruss, P.

Cell and Tissue Research. (1997).